Improving Defences at the Portal of HIV Entry: Mucosal and Innate Immunity

نویسندگان

  • Robin J Shattock
  • Barton F Haynes
  • Bali Pulendran
  • Jorge Flores
  • José Esparza
چکیده

Robin Shattock is at St George’s, University of London, London, United Kingdom. Barton Haynes is at the Human Vaccine Institute, Duke University School of Medicine, Durham, NC, United States. Bali Pulendran is at the Emory Vaccine Center & Department of Pathology, Emory University, Atlanta, GA, United States, Jorge Flores is at the Division of AIDS, National Institutes of Health, Bethesda, MD, United States. José Esparza is at the Bill & Melinda Gates Foundation, Seattle, WA, United States.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Section I: Roadblocks to Inducing Protective Adaptive Immunity at Mucosal Surfaces

The workshop on Improving Defences at the Portal of Entry: Mucosal and Innate Immunity was held in June of 2007 in Durham, North Carolina, United States, with the goal of identifying key scientific issues in mucosal (section I) and innate (section II) immunity, as it pertains to immune protection against HIV infection, that have emerged since the Enterprise Strategic Plan was first published in...

متن کامل

Natural Immunity to HIV: A Delicate Balance between Strength and Control

Understanding how the mucosal immune system in the human female reproductive tract might prevent or facilitate HIV infection has important implications for the design of effective interventions. We and others have established cohorts of highly-exposed, HIV-seronegative individuals, such as HIV-uninfected commercial sex workers, who have remained HIV-negative after more than 5 years of active pr...

متن کامل

Epidermal mucus, a major determinant in fish health: a review

Fish epidermal mucus contains innate immune components, secreted by globlet cells that provide the primary defence against different pathogenic microbes and act as a barrier between fish and its immediate niche. The major function of mucus includes entrapment and sloughing of microbes. The mucus also contains many factors such as antimicrobial peptides (AMPs), lysozymes, lectins, proteases, etc...

متن کامل

Frequency Distribution Candidal Vaginitis in Women Referred to Health Centers in Yazd

Introduction: The vaginal flora is a dynamic ecosystem that can be easily altered. Although, there are four causes of vaginal discharges which cover almost 95% of vaginaitis. Candidal Vaginaitis is an infection of the vagina’s mucous membranes by Candida albicans (CA). Present study attempted to Candidal Vaginitis in women referred to health centers in Yazd and the role of innate & cell-mediate...

متن کامل

Characterization of an Effective CTL Response against HIV and SIV Infections

A vaccine inducing protective immunity in mucosal tissues and secretions may stop or limit HIV infection. Although cytotoxic T lymphocytes (CTLs) are clearly associated with control of viral replication in HIV and simian immunodeficiency virus (SIV) infections, there are examples of uncontrolled viral replication in the face of strong CD8+ T-cell responses. The number of functions, breadth, avi...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • PLoS Medicine

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2008